ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SCG2

Full Name:

secretogranin II (chromogranin C)

Alias:

CHGC|SN|SgII

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q35-q36

Physical Location:

224169901-224175364 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20254 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

M25756

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003469.3	NP_003460.2	NC_000002.10 range: 224169901..224175364, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (9473216)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0042056	chemoattractant activity	Molecular Function	IDA (9473216)
GO:0005125	cytokine activity	Molecular Function	IDA (14970115)
GO:0000165	MAPKKK cascade	Biological Process	IDA (14970115)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (14970115)
GO:0043542	endothelial cell migration	Biological Process	TAS (9473216)
GO:0048245	eosinophil chemotaxis	Biological Process	IDA (9473216)
GO:0009306	protein secretion	Biological Process	TAS (2745426)
GO:0007242	intracellular signaling cascade	Biological Process	IDA (9473216)
GO:0006954	inflammatory response	Biological Process	TAS (14970115)
GO:0006928	cell motility	Biological Process	IDA (9473216)
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process	IDA (14970115)
GO:0001937	negative regulation of endothelial cell proliferation	Biological Process	TAS (9473216)
GO:0001525	angiogenesis	Biological Process	IDA (14970115)
GO:0050930	induction of positive chemotaxis	Biological Process	IDA (9473216)