ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MLPH

Full Name:

melanophilin

Alias:

MGC2771|MGC59733|SLAC2-A

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q37.3

Physical Location:

238060616-238128699 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 171531 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0017137	Rab GTPase binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006886	intracellular protein transport	Biological Process	IEA