ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hmox2

Full Name:

heme oxygenase (decycling) 2

Alias:

Ho-2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q12

Physical Location:

10914156-10929447 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3163 Symbol (Name): HMOX2 (heme oxygenase (decycling) 2)

Ortholog Status:

The human GeneID 3163 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.10241
Original ID2:		Hmox2
Fold Change:		1.27
P Value:		0.00668
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024387.1	NP_077363.1	NC_005109.2 range: 10914156..10929447, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0009055	electron carrier activity	Molecular Function	ISS
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0004392	heme oxygenase (decyclizing) activity	Molecular Function	IDA (2185251)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004392	heme oxygenase (decyclizing) activity	Molecular Function	TAS (12114211)
GO:0004392	heme oxygenase (decyclizing) activity	Molecular Function	ISS
GO:0004392	heme oxygenase (decyclizing) activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006788	heme oxidation	Biological Process	IEA
GO:0006788	heme oxidation	Biological Process	TAS (12114211)
GO:0006979	response to oxidative stress	Biological Process	IDA (11950143)