ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aco2

Full Name:

aconitase 2, mitochondrial

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q34

Physical Location:

120223787-120266943 on NC_005106.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 50 Symbol (Name): ACO2 (aconitase 2, mitochondrial)

Ortholog Status:

The human GeneID 50 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Aco2
Fold Change:		1.2
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024398.2	NP_077374.2	NC_005106.2 range: 120223787..120266943

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0003994	aconitate hydratase activity	Molecular Function	IDA (12139479)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0051539	4 iron, 4 sulfur cluster binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	ISS
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0003994	aconitate hydratase activity	Molecular Function	ISS
GO:0003994	aconitate hydratase activity	Molecular Function	IEA
GO:0006099	tricarboxylic acid cycle	Biological Process	ISS
GO:0006101	citrate metabolic process	Biological Process	ISS
GO:0008152	metabolic process	Biological Process	IEA
GO:0006099	tricarboxylic acid cycle	Biological Process	IEA