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Gene Information
Gene ID:79251
Full Name:aspartoacylase
Organism:Rattus norvegicus (Rat)
Physical Location:60178508-60199206 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 443    Symbol (Name): ASPA (aspartoacylase (Canavan disease))
Ortholog Status:The human GeneID 443 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Aspa
Fold Change:1.12
P Value:0.01
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024399.1NP_077375.1NC_005109.2 range: 60178508..60199206, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (16935940)
GO:0005737cytoplasmCellular ComponentIDA (16935940)
GO:0016788hydrolase activity, acting on ester bondsMolecular FunctionIEA
GO:0019807aspartoacylase activityMolecular FunctionIEA
GO:0019807aspartoacylase activityMolecular FunctionTAS (12524181)
GO:0008152metabolic processBiological ProcessIEA
GO:0022010myelination in the central nervous systemBiological ProcessIEP (12524181)
GO:0048714positive regulation of oligodendrocyte differentiationBiological ProcessIMP (16634055)
Other Database Cross Links
NCBI Entrez Gene:79251