ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bhlhb2

Full Name:

basic helix-loop-helix domain containing, class B2

Alias:

Dec1|SHARP-2|Sharp2|Stra13|Stra14

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q41

Physical Location:

144139485-144145185 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8553 Symbol (Name): BHLHB2 (basic helix-loop-helix domain containing, class B, 2)

Ortholog Status:

The human GeneID 8553 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Bhlhb2
Fold Change:		1.25
P Value:		0.006
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053328.1	NP_445780.1	NC_005103.2 range: 144139485..144145185

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IMP (12954728)
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0003677	DNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0003677	DNA binding	Molecular Function	ISS
GO:0016564	transcription repressor activity	Molecular Function	IMP (12954728)
GO:0048168	regulation of neuronal synaptic plasticity	Biological Process	IEP (9532582)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0009649	entrainment of circadian clock	Biological Process	IDA (12397359)
GO:0007399	nervous system development	Biological Process	NAS (9532582)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0048168	regulation of neuronal synaptic plasticity	Biological Process	NAS (9532582)