Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:79431
Full Name:basic helix-loop-helix domain containing, class B2
Organism:Rattus norvegicus (Rat)
Genetic Location:4q41
Physical Location:144139485-144145185 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 8553    Symbol (Name): BHLHB2 (basic helix-loop-helix domain containing, class B, 2)
Ortholog Status:The human GeneID 8553 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Bhlhb2
Fold Change:1.25
P Value:0.006
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053328.1NP_445780.1NC_005103.2 range: 144139485..144145185
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIMP (12954728)
GO:0016564transcription repressor activityMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0016564transcription repressor activityMolecular FunctionIMP (12954728)
GO:0048168regulation of neuronal synaptic plasticityBiological ProcessIEP (9532582)
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessISS
GO:0009649entrainment of circadian clockBiological ProcessIDA (12397359)
GO:0007399nervous system developmentBiological ProcessNAS (9532582)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0048168regulation of neuronal synaptic plasticityBiological ProcessNAS (9532582)
Other Database Cross Links
NCBI Entrez Gene:79431