ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

79558

Symbol:

Acvr1

Full Name:

activin A receptor, type 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q21

Physical Location:

40191726-40260487 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 90 Symbol (Name): ACVR1 (activin A receptor, type I)

Ortholog Status:

The human GeneID 90 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Acvr1
Fold Change:		1.14
P Value:		0.009
Note:		Differential expression between ethanol and water groups in amygdala

Gene Information

Original ID1:		Acvr1
Fold Change:		1.2
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024486.1	NP_077812.1	NC_005102.2 range: 40191726..40260487, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045177	apical part of cell	Cellular Component	ISS
GO:0048179	activin receptor complex	Cellular Component	IMP (12844345)
GO:0045177	apical part of cell	Cellular Component	IEA
GO:0048179	activin receptor complex	Cellular Component	IEA
GO:0048179	activin receptor complex	Cellular Component	IDA (8248234)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	ISS
GO:0048179	activin receptor complex	Cellular Component	ISS
GO:0046332	SMAD binding	Molecular Function	IMP (12844345)
GO:0046332	SMAD binding	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	ISS
GO:0046332	SMAD binding	Molecular Function	IEA
GO:0016361	activin receptor activity, type I	Molecular Function	ISS
GO:0016361	activin receptor activity, type I	Molecular Function	IMP (12844345)
GO:0016361	activin receptor activity, type I	Molecular Function	ISS
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0019838	growth factor binding	Molecular Function	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016361	activin receptor activity, type I	Molecular Function	IDA (8248234)
GO:0016361	activin receptor activity, type I	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005025	transforming growth factor beta receptor activity, type I	Molecular Function	ISS
GO:0050431	transforming growth factor beta binding	Molecular Function	ISS
GO:0048185	activin binding	Molecular Function	ISS
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0048185	activin binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Molecular Function	TAS (12770730)
GO:0004702	receptor signaling protein serine/threonine kinase activity	Molecular Function	IMP (12844345)
GO:0005024	transforming growth factor beta receptor activity	Molecular Function	IEA
GO:0050431	transforming growth factor beta binding	Molecular Function	IEA
GO:0060037	pharyngeal system development	Biological Process	ISS
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	IMP
GO:0051145	smooth muscle cell differentiation	Biological Process	ISS
GO:0030278	regulation of ossification	Biological Process	IEA
GO:0032926	negative regulation of activin receptor signaling pathway	Biological Process	IEA
GO:0001702	gastrulation with mouth forming second	Biological Process	ISS
GO:0045941	positive regulation of transcription	Biological Process	ISS
GO:0045941	positive regulation of transcription	Biological Process	IEA
GO:0051145	smooth muscle cell differentiation	Biological Process	IEA
GO:0048641	regulation of skeletal muscle development	Biological Process	IEP
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0043066	negative regulation of apoptosis	Biological Process	IEA
GO:0032926	negative regulation of activin receptor signaling pathway	Biological Process	ISS
GO:0030278	regulation of ossification	Biological Process	ISS
GO:0009790	embryonic development	Biological Process	ISS
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IEA
GO:0002526	acute inflammatory response	Biological Process	ISS
GO:0002526	acute inflammatory response	Biological Process	IEA
GO:0001755	neural crest cell migration	Biological Process	ISS
GO:0001755	neural crest cell migration	Biological Process	IEA
GO:0001707	mesoderm formation	Biological Process	ISS
GO:0001707	mesoderm formation	Biological Process	IEA
GO:0001701	in utero embryonic development	Biological Process	ISS
GO:0001701	in utero embryonic development	Biological Process	IEA
GO:0001655	urogenital system development	Biological Process	IMP
GO:0001569	patterning of blood vessels	Biological Process	ISS
GO:0001569	patterning of blood vessels	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IMP (12844345)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0007507	heart development	Biological Process	ISS
GO:0007507	heart development	Biological Process	IEA
GO:0007498	mesoderm development	Biological Process	ISS
GO:0007498	mesoderm development	Biological Process	IEA
GO:0007369	gastrulation	Biological Process	ISS
GO:0007369	gastrulation	Biological Process	IEA
GO:0007368	determination of left/right symmetry	Biological Process	ISS
GO:0007368	determination of left/right symmetry	Biological Process	IEA
GO:0007281	germ cell development	Biological Process	ISS
GO:0007281	germ cell development	Biological Process	IEA
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (12770730)
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	ISS