ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

796

Symbol:

CALCA

Full Name:

calcitonin-related polypeptide alpha

Alias:

CALC1|CGRP|CGRP-I|CGRP1|CT|KC|MGC126648

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11p15.2-p15.1

Physical Location:

14944791-14950407 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

M26095

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

CALCA

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001033952.1	NP_001029124.1	NC_000011.8 range: 14944791..14950407, complement
NM_001033953.1	NP_001029125.1	NC_000011.8 range: 14944791..14950407, complement
NM_001741.2	NP_001732.1	NC_000011.8 range: 14944791..14950407, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (2408883\|18057382)
GO:0005737	cytoplasm	Cellular Component	IDA (17267696)
GO:0031716	calcitonin receptor binding	Molecular Function	IPI (8078488\|8940110)
GO:0005179	hormone activity	Molecular Function	IEA
GO:0043542	endothelial cell migration	Biological Process	IDA (17267696)
GO:0045651	positive regulation of macrophage differentiation	Biological Process	IDA (10822112)
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	IDA (10822112)
GO:0045762	positive regulation of adenylate cyclase activity	Biological Process	IDA (8078488\|11014233)
GO:0045776	negative regulation of blood pressure	Biological Process	IDA (10642343)
GO:0045779	negative regulation of bone resorption	Biological Process	IDA (10822112\|17241109)
GO:0045909	positive regulation of vasodilation	Biological Process	IDA (3266556)
GO:0051480	cytosolic calcium ion homeostasis	Biological Process	IDA (9685362)
GO:0032757	positive regulation of interleukin-8 production	Biological Process	IDA (16904178)
GO:0032730	positive regulation of interleukin-1 alpha production	Biological Process	IDA (16904178)
GO:0032147	activation of protein kinase activity	Biological Process	IDA (17983652)
GO:0001944	vasculature development	Biological Process	IDA (17267696)
GO:0001976	regulation of systemic arterial blood pressure by neurological process	Biological Process	IDA (10642343)
GO:0007159	leukocyte adhesion	Biological Process	IDA (1326102)
GO:0007190	activation of adenylate cyclase activity	Biological Process	IDA (10822112\|16014619)
GO:0007267	cell-cell signaling	Biological Process	TAS (2408883)
GO:0007566	embryo implantation	Biological Process	IDA (17983652)
GO:0016481	negative regulation of transcription	Biological Process	IDA (11014233)
GO:0001935	endothelial cell proliferation	Biological Process	IDA (17267696)
GO:0051482	elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	Biological Process	IDA (8078488\|9685362)