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Gene Information
Gene ID:79751
Symbol:SLC25A22
Full Name:solute carrier family 25 (mitochondrial carrier: glutamate), member 22
Alias:FLJ13044|GC1
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11p15.5
Physical Location:780474-786220 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.99486
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024698.4NP_078974.1NC_000011.8 range: 780474..786220, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005743mitochondrial inner membraneCellular ComponentIDA (11897791)
GO:0015293symporter activityMolecular FunctionIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0005313L-glutamate transmembrane transporter activityMolecular FunctionIDA (11897791)
GO:0015813L-glutamate transportBiological ProcessIDA (11897791)
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:79751
HGNC:19954
Ensembl:ENSG00000177542
MIM:609302
HPRD:15356
HuGE Navigator:79751
dbSNP:SLC25A22
GeneCard:SLC25A22
AceView:SLC25A22