ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC25A22

Full Name:

solute carrier family 25 (mitochondrial carrier: glutamate), member 22

Alias:

FLJ13044|GC1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11p15.5

Physical Location:

780474-786220 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.99486
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024698.4	NP_078974.1	NC_000011.8 range: 780474..786220, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (11897791)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0005313	L-glutamate transmembrane transporter activity	Molecular Function	IDA (11897791)
GO:0015813	L-glutamate transport	Biological Process	IDA (11897791)
GO:0006810	transport	Biological Process	IEA