ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

STAM

Full Name:

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Alias:

DKFZp686J2352|STAM1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p14-p13

Physical Location:

17726129-17797912 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.441498
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

STAM

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003473.2	NP_003464.1	NC_000010.9 range: 17726129..17797912

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (10567358\|12218189\|15962011)
GO:0005070	SH3/SH2 adaptor activity	Molecular Function	TAS (8780729)
GO:0005515	protein binding	Molecular Function	IPI (10383417)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (8780729)