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Gene Information
Gene ID:81574
Symbol:Scn1a
Full Name:sodium channel, voltage-gated, type I, alpha
Organism:Rattus norvegicus (Rat)
Chromosome:3
Genetic Location:3q21
Physical Location:48238527-48364142 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6323    Symbol (Name): SCN1A (sodium channel, voltage-gated, type I, alpha subunit)
Ortholog Status:The human GeneID 6323 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.32079
Original ID2:Scn1a
Fold Change:1.39
P Value:0.00107
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_030875.1NP_110502.1NC_005102.2 range: 48238527..48364142, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0014704intercalated discCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIDA (17273863)
GO:0043194initial segmentCellular ComponentISS
GO:0043025cell somaCellular ComponentISS
GO:0033268node of RanvierCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0030424axonCellular ComponentISS
GO:0030315T-tubuleCellular ComponentISS
GO:0005624membrane fractionCellular ComponentISS
GO:0001518voltage-gated sodium channel complexCellular ComponentIDA (15664695)
GO:0001518voltage-gated sodium channel complexCellular ComponentIEA
GO:0005248voltage-gated sodium channel activityMolecular FunctionTAS (3754035)
GO:0031402sodium ion bindingMolecular FunctionIDA (15664695)
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005248voltage-gated sodium channel activityMolecular FunctionIC (15917456)
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0005248voltage-gated sodium channel activityMolecular FunctionIDA (15664695)
GO:0005248voltage-gated sodium channel activityMolecular FunctionIEA
GO:0005248voltage-gated sodium channel activityMolecular FunctionIMP (17273863)
GO:0005248voltage-gated sodium channel activityMolecular FunctionISS
GO:0042391regulation of membrane potentialBiological ProcessISS
GO:0019228regulation of action potential in neuronBiological ProcessTAS (3754035)
GO:0019228regulation of action potential in neuronBiological ProcessISS
GO:0006811ion transportBiological ProcessIEA
GO:0006814sodium ion transportBiological ProcessIEA
GO:0006814sodium ion transportBiological ProcessISS
GO:0007628adult walking behaviorBiological ProcessISS
GO:0001508regulation of action potentialBiological ProcessISS
GO:0019227action potential propagationBiological ProcessISS
GO:0019228regulation of action potential in neuronBiological ProcessIDA (15664695|15917456)
GO:0019228regulation of action potential in neuronBiological ProcessIMP (17273863)
GO:0050884neuromuscular process controlling postureBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:81574
RGD:69364
Ensembl:ENSRNOG00000005989
dbSNP:Scn1a