ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adar

Full Name:

adenosine deaminase, RNA-specific

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

181935245-181956038 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 103 Symbol (Name): ADAR (adenosine deaminase, RNA-specific)

Ortholog Status:

The human GeneID 103 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adar
Fold Change:		-1.14
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Adar
Fold Change:		-1.16
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031006.1	NP_112268.1	NC_005101.2 range: 181935245..181956038

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (7862132)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003726	double-stranded RNA adenosine deaminase activity	Molecular Function	IEA
GO:0003725	double-stranded RNA binding	Molecular Function	IEA
GO:0003725	double-stranded RNA binding	Molecular Function	IMP (7862132)
GO:0003726	double-stranded RNA adenosine deaminase activity	Molecular Function	IDA (7862132)
GO:0006382	adenosine to inosine editing	Biological Process	TAS (7862132)
GO:0006397	mRNA processing	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0016553	base conversion or substitution editing	Biological Process	ISS
GO:0031047	gene silencing by RNA	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA