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Gene Information
Gene ID:81636
Full Name:adenylate cyclase 2
Organism:Rattus norvegicus (Rat)
Genetic Location:17p14
Physical Location:4543500-5040432 on NC_005116.2
Gene Type:protein-coding
Human Ortholog:GeneID: 108    Symbol (Name): ADCY2 (adenylate cyclase 2 (brain))
Ortholog Status:The human GeneID 108 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.10731
Original ID2:Adcy2
Fold Change:1.25
P Value:0.00954
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031007.1NP_112269.1NC_005116.2 range: 4543500..5040432
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0030425dendriteCellular ComponentISS
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0004016adenylate cyclase activityMolecular FunctionIDA (1719547)
GO:0004016adenylate cyclase activityMolecular FunctionIEA
GO:0006171cAMP biosynthetic processBiological ProcessIEA
GO:0007242intracellular signaling cascadeBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:81636