ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adcy2

Full Name:

adenylate cyclase 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

17p14

Physical Location:

4543500-5040432 on NC_005116.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 108 Symbol (Name): ADCY2 (adenylate cyclase 2 (brain))

Ortholog Status:

The human GeneID 108 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.10731
Original ID2:		Adcy2
Fold Change:		1.25
P Value:		0.00954
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031007.1	NP_112269.1	NC_005116.2 range: 4543500..5040432

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030425	dendrite	Cellular Component	ISS
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004016	adenylate cyclase activity	Molecular Function	IDA (1719547)
GO:0004016	adenylate cyclase activity	Molecular Function	IEA
GO:0006171	cAMP biosynthetic process	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA