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Gene Information
Gene ID:81643
Full Name:5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Organism:Rattus norvegicus (Rat)
Genetic Location:9q33
Physical Location:70676743-70696864 on NC_005108.2
Gene Type:protein-coding
Human Ortholog:GeneID: 471    Symbol (Name): ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)
Ortholog Status:The human GeneID 471 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.15114
Original ID2:Atic
Fold Change:1.58
P Value:0
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Atic
Fold Change:1.32
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031014.2NP_112276.2NC_005108.2 range: 70676743..70696864
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0003937IMP cyclohydrolase activityMolecular FunctionIDA (9332377)
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0004643phosphoribosylaminoimidazolecarboxamide formyltransferase activityMolecular FunctionIEA
GO:0004643phosphoribosylaminoimidazolecarboxamide formyltransferase activityMolecular FunctionIDA (9332377)
GO:0003937IMP cyclohydrolase activityMolecular FunctionIEA
GO:0006164purine nucleotide biosynthetic processBiological ProcessIEA
GO:0006188IMP biosynthetic processBiological ProcessIEA
GO:0006189'de novo' IMP biosynthetic processBiological ProcessNAS (9332377)
GO:0031100organ regenerationBiological ProcessIEP (9332377)
Other Database Cross Links
NCBI Entrez Gene:81643