ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atf2

Full Name:

activating transcription factor 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q23

Physical Location:

56427235-56496472 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1386 Symbol (Name): ATF2 (activating transcription factor 2)

Ortholog Status:

The human GeneID 1386 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		81647
Fold Change:		1.181
P Value:		0.0365
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031018.1	NP_112280.1	NC_005102.2 range: 56427235..56496472, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0003677	DNA binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0016563	transcription activator activity	Molecular Function	IDA (12196528)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (17428807)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (17428807)
GO:0007399	nervous system development	Biological Process	NAS (12196528)
GO:0042423	catecholamine biosynthetic process	Biological Process	IPI (12196528)