ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gatm

Full Name:

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Alias:

MGC93388

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q35

Physical Location:

109558012-109565492 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2628 Symbol (Name): GATM (glycine amidinotransferase (L-arginine:glycine amidinotransferase))

Ortholog Status:

The human GeneID 2628 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.33427
Original ID2:		Gatm
Fold Change:		1.36
P Value:		0.00027
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_575224.1	XP_575224.1	NC_005102.2 range: 109558012..109565492, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005758	mitochondrial intermembrane space	Cellular Component	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0015068	glycine amidinotransferase activity	Molecular Function	ISS
GO:0015067	amidinotransferase activity	Molecular Function	IDA (8035648)
GO:0043434	response to peptide hormone stimulus	Biological Process	IDA (8021264)
GO:0042246	tissue regeneration	Biological Process	IEP (16626512)
GO:0010033	response to organic substance	Biological Process	IDA (15600250)
GO:0009790	embryonic development	Biological Process	IEP (15918910)
GO:0007584	response to nutrient	Biological Process	IDA (11595668)
GO:0006979	response to oxidative stress	Biological Process	IEP (8837048)
GO:0006601	creatine biosynthetic process	Biological Process	TAS (8021264)
GO:0006601	creatine biosynthetic process	Biological Process	ISS
GO:0046689	response to mercury ion	Biological Process	IDA (15600250)