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Gene Information
Gene ID:81666
Symbol:Gnaq
Full Name:guanine nucleotide binding protein, alpha q polypeptide
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q43
Physical Location:219520997-219764400 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2776    Symbol (Name): GNAQ (guanine nucleotide binding protein (G protein), q polypeptide)
Ortholog Status:The human GeneID 2776 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gnaq
Fold Change:-1.27
P Value:0
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Gnaq
Fold Change:-1.33
P Value:0
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Gnaq
Fold Change:-1.2
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Gnaq
Fold Change:-1.3
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031036.1NP_112298.1NC_005100.2 range: 219520997..219764400
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005901caveolaCellular ComponentIDA (16730745)
GO:0005886plasma membraneCellular ComponentISS
GO:0005834heterotrimeric G-protein complexCellular ComponentTAS (12900409)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0003924GTPase activityMolecular FunctionTAS (14534355)
GO:0019001guanyl nucleotide bindingMolecular FunctionIEA
GO:0016322neuron remodelingBiological ProcessISS
GO:0016322neuron remodelingBiological ProcessIEA
GO:0009791post-embryonic developmentBiological ProcessISS
GO:0021884forebrain neuron developmentBiological ProcessISS
GO:0042733embryonic digit morphogenesisBiological ProcessIEA
GO:0042733embryonic digit morphogenesisBiological ProcessISS
GO:0043065positive regulation of apoptosisBiological ProcessTAS (12900409)
GO:0043267negative regulation of potassium ion transportBiological ProcessIMP (9614229)
GO:0045634regulation of melanocyte differentiationBiological ProcessIEA
GO:0045634regulation of melanocyte differentiationBiological ProcessISS
GO:0048066pigmentation during developmentBiological ProcessIEA
GO:0048066pigmentation during developmentBiological ProcessISS
GO:0048661positive regulation of smooth muscle cell proliferationBiological ProcessIMP (14981460)
GO:0060158dopamine receptor, phospholipase C activating pathwayBiological ProcessIEA
GO:0060158dopamine receptor, phospholipase C activating pathwayBiological ProcessISS
GO:0007610behaviorBiological ProcessISS
GO:0007507heart developmentBiological ProcessISS
GO:0001501skeletal developmentBiological ProcessISS
GO:0001508regulation of action potentialBiological ProcessIEA
GO:0001508regulation of action potentialBiological ProcessISS
GO:0006471protein amino acid ADP-ribosylationBiological ProcessIEA
GO:0006916anti-apoptosisBiological ProcessIMP (16466740)
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS
GO:0007189G-protein signaling, adenylate cyclase activating pathwayBiological ProcessIEA
GO:0007189G-protein signaling, adenylate cyclase activating pathwayBiological ProcessISS
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)Biological ProcessIMP (9677408)
GO:0007202activation of phospholipase C activityBiological ProcessIMP (14981460)
GO:0007215glutamate signaling pathwayBiological ProcessIEA
GO:0007215glutamate signaling pathwayBiological ProcessISS
GO:0007507heart developmentBiological ProcessIEA
GO:0001501skeletal developmentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:81666
RGD:620770
Ensembl:ENSRNOG00000014183
dbSNP:Gnaq