ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdpk1

Full Name:

3-phosphoinositide dependent protein kinase-1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q12

Physical Location:

13329707-13394085 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5170 Symbol (Name): PDPK1 (3-phosphoinositide dependent protein kinase-1)

Ortholog Status:

The human GeneID 5170 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pdpk1
Fold Change:		-1.45
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Pdpk1
Fold Change:		-1.47
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031081.1	NP_112343.1	NC_005109.2 range: 13329707..13394085, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (16314505)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component	IEA
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	IDA (16314505)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019901	protein kinase binding	Molecular Function	IDA (14585963)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004676	3-phosphoinositide-dependent protein kinase activity	Molecular Function	IDA (14585963\|16314505)
GO:0004676	3-phosphoinositide-dependent protein kinase activity	Molecular Function	IEA
GO:0004676	3-phosphoinositide-dependent protein kinase activity	Molecular Function	ISS
GO:0005158	insulin receptor binding	Molecular Function	IDA (16314505)
GO:0005515	protein binding	Molecular Function	ISS
GO:0007242	intracellular signaling cascade	Biological Process	ISS
GO:0006972	hyperosmotic response	Biological Process	ISS
GO:0006972	hyperosmotic response	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0048041	focal adhesion formation	Biological Process	IMP (14585963)