Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:81745
Full Name:3-phosphoinositide dependent protein kinase-1
Organism:Rattus norvegicus (Rat)
Genetic Location:10q12
Physical Location:13329707-13394085 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5170    Symbol (Name): PDPK1 (3-phosphoinositide dependent protein kinase-1)
Ortholog Status:The human GeneID 5170 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pdpk1
Fold Change:-1.45
P Value:0.003
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Pdpk1
Fold Change:-1.47
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031081.1NP_112343.1NC_005109.2 range: 13329707..13394085, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentISS
GO:0005829cytosolCellular ComponentIDA (16314505)
GO:0005737cytoplasmCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016023cytoplasmic membrane-bounded vesicleCellular ComponentIEA
GO:0016023cytoplasmic membrane-bounded vesicleCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIDA (16314505)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0019901protein kinase bindingMolecular FunctionIDA (14585963)
GO:0005524ATP bindingMolecular FunctionIEA
GO:00046763-phosphoinositide-dependent protein kinase activityMolecular FunctionIDA (14585963|16314505)
GO:00046763-phosphoinositide-dependent protein kinase activityMolecular FunctionIEA
GO:00046763-phosphoinositide-dependent protein kinase activityMolecular FunctionISS
GO:0005158insulin receptor bindingMolecular FunctionIDA (16314505)
GO:0005515protein bindingMolecular FunctionISS
GO:0007242intracellular signaling cascadeBiological ProcessISS
GO:0006972hyperosmotic responseBiological ProcessISS
GO:0006972hyperosmotic responseBiological ProcessIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0048041focal adhesion formationBiological ProcessIMP (14585963)
Other Database Cross Links
NCBI Entrez Gene:81745