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Gene Information
Gene ID:81812
Full Name:thyroid hormone receptor alpha
Organism:Rattus norvegicus (Rat)
Genetic Location:10q31
Physical Location:87514442-87542305 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 7067    Symbol (Name): THRA (thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian))
Ortholog Status:The human GeneID 7067 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:81812
Fold Change:0.605
P Value:0.041
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001017960.1NP_001017960.1NC_005109.2 range: 87514442..87542305
NM_031134.2NP_112396.2NC_005109.2 range: 87514442..87542305
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (16356627)
GO:0005829cytosolCellular ComponentIDA (16155104)
GO:0005634nucleusCellular ComponentIDA (16155104|16356627)
GO:0016564transcription repressor activityMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionIDA (12039959)
GO:0042803protein homodimerization activityMolecular FunctionIDA (8407924)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (8407924)
GO:0046982protein heterodimerization activityMolecular FunctionIDA (8407924)
GO:0005515protein bindingMolecular FunctionISS
GO:0004887thyroid hormone receptor activityMolecular FunctionIDA (12039959)
GO:0004879ligand-dependent nuclear receptor activityMolecular FunctionISS
GO:0003727single-stranded RNA bindingMolecular FunctionIDA (16356627)
GO:0030528transcription regulator activityMolecular FunctionISS
GO:0043433negative regulation of transcription factor activityBiological ProcessIDA (2537467)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (12039959)
GO:0016481negative regulation of transcriptionBiological ProcessISS
GO:0009887organ morphogenesisBiological ProcessISS
GO:0008016regulation of heart contractionBiological ProcessISS
GO:0001503ossificationBiological ProcessISS
GO:0001502cartilage condensationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:81812