ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Thra

Full Name:

thyroid hormone receptor alpha

Alias:

ERBA1|Thra1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q31

Physical Location:

87514442-87542305 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7067 Symbol (Name): THRA (thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian))

Ortholog Status:

The human GeneID 7067 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		81812
Fold Change:		0.605
P Value:		0.041
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (16356627)
GO:0005829	cytosol	Cellular Component	IDA (16155104)
GO:0005634	nucleus	Cellular Component	IDA (16155104\|16356627)
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0016563	transcription activator activity	Molecular Function	IDA (12039959)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (8407924)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (8407924)
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (8407924)
GO:0005515	protein binding	Molecular Function	ISS
GO:0004887	thyroid hormone receptor activity	Molecular Function	IDA (12039959)
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	ISS
GO:0003727	single-stranded RNA binding	Molecular Function	IDA (16356627)
GO:0030528	transcription regulator activity	Molecular Function	ISS
GO:0043433	negative regulation of transcription factor activity	Biological Process	IDA (2537467)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12039959)
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0008016	regulation of heart contraction	Biological Process	ISS
GO:0001503	ossification	Biological Process	ISS
GO:0001502	cartilage condensation	Biological Process	ISS