ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Klf10

Full Name:

Kruppel-like factor 10

Alias:

Tieg

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q22

Physical Location:

73821280-73827133 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7071 Symbol (Name): KLF10 (Kruppel-like factor 10)

Ortholog Status:

The human GeneID 7071 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Klf10
Fold Change:		1.27
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031135.2	NP_112397.1	NC_005106.2 range: 73821280..73827133, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0006917	induction of apoptosis	Biological Process	IDA (9153278)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0030282	bone mineralization	Biological Process	ISS
GO:0042127	regulation of cell proliferation	Biological Process	IDA (9153278)
GO:0045449	regulation of transcription	Biological Process	ISS
GO:0045672	positive regulation of osteoclast differentiation	Biological Process	IEA
GO:0045672	positive regulation of osteoclast differentiation	Biological Process	ISS
GO:0030282	bone mineralization	Biological Process	IEA