ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sf3b1

Full Name:

splicing factor 3b, subunit 1

Alias:

155kDa|2810001M05Rik|AA409119|Prp10|SAP155|SF3b155|TA-8|Targ4

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 C1.2|1 28.9 cM

Physical Location:

55042012-55100575 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23451 Symbol (Name): SF3B1 (splicing factor 3b, subunit 1, 155kDa)

Ortholog Status:

The human GeneID 23451 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sf3b1
Original ID2:		AI844532

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws1/Alcw5	Chronic Alcohol Withdrawal	1		28-47 (cM)	6.5	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031179.2	NP_112456.2	NC_000067.5 range: 55042012..55100575, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005681	spliceosome	Cellular Component	ISS (11252167)
GO:0005634	nucleus	Cellular Component	IEA
GO:0031202	RNA splicing factor activity, transesterification mechanism	Molecular Function	ISS (11252167)
GO:0005515	protein binding	Molecular Function	IPI (15741318)
GO:0005488	binding	Molecular Function	IEA
GO:0003682	chromatin binding	Molecular Function	IDA (15741318)
GO:0006397	mRNA processing	Biological Process	IEA
GO:0008380	RNA splicing	Biological Process	IEA
GO:0009952	anterior/posterior pattern formation	Biological Process	IGI (15741318)
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	ISS (11252167)