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Gene Information
Gene ID:825
Full Name:calpain 3, (p94)
Organism:Homo sapiens (Human)
Genetic Location:15q15.1-q21.1
Physical Location:40427592-40491806 on NC_000015.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI978885
Fold Change:-1.7, -1.8
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:Hs.143261
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000070.2NP_000061.1NC_000015.8 range: 40427592..40491806
NM_024344.1NP_077320.1NC_000015.8 range: 40427592..40491806
NM_173087.1NP_775110.1NC_000015.8 range: 40427592..40491806
NM_173088.1NP_775111.1NC_000015.8 range: 40427592..40491806
NM_173089.1NP_775112.1NC_000015.8 range: 40427592..40491806
NM_173090.1NP_775113.1NC_000015.8 range: 40427592..40491806
NM_212464.2NP_997629.1NC_000015.8 range: 40427592..40491806
NM_212465.2NP_997630.1NC_000015.8 range: 40427592..40491806
NM_212467.2NP_997632.1NC_000015.8 range: 40427592..40491806
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentTAS (7720071)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0004198calcium-dependent cysteine-type endopeptidase activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0004871signal transducer activityMolecular FunctionTAS (7720071)
GO:0004198calcium-dependent cysteine-type endopeptidase activityMolecular FunctionTAS (9642272)
GO:0006508proteolysisBiological ProcessIEA
GO:0006508proteolysisBiological ProcessTAS (9642272)
GO:0007517muscle developmentBiological ProcessTAS (7720071|9642272)
Other Database Cross Links
NCBI Entrez Gene:825
HuGE Navigator:825