ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PICALM

Full Name:

phosphatidylinositol binding clathrin assembly protein

Alias:

CALM|CLTH|LAP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q14

Physical Location:

85346132-85457755 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.163893
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005905	coated pit	Cellular Component	ISS
GO:0030118	clathrin coat	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005905	coated pit	Cellular Component	IDA (10436022)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0030276	clathrin binding	Molecular Function	ISS
GO:0005543	phospholipid binding	Molecular Function	IEA
GO:0005545	phosphatidylinositol binding	Molecular Function	ISS
GO:0005545	phosphatidylinositol binding	Molecular Function	IEA
GO:0030276	clathrin binding	Molecular Function	IDA (10436022)
GO:0006898	receptor-mediated endocytosis	Biological Process	ISS
GO:0006898	receptor-mediated endocytosis	Biological Process	IDA (10436022)
GO:0048268	clathrin coat assembly	Biological Process	IEA