ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prep

Full Name:

prolyl endopeptidase

Alias:

rPop

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20q13

Physical Location:

49024916-49144669 on NC_005119.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5550 Symbol (Name): PREP (prolyl endopeptidase)

Ortholog Status:

The human GeneID 5550 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.11058
Original ID2:		Prep
Fold Change:		1.41
P Value:		0.00109
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031324.1	NP_112614.1	NC_005119.2 range: 49024916..49144669

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (11792464)
GO:0004175	endopeptidase activity	Molecular Function	IDA (11792464)
GO:0004287	prolyl oligopeptidase activity	Molecular Function	IDA (17415460)
GO:0004287	prolyl oligopeptidase activity	Molecular Function	IEA
GO:0042277	peptide binding	Molecular Function	IDA (17415460)
GO:0006508	proteolysis	Biological Process	IDA (11792464\|17415460)
GO:0006508	proteolysis	Biological Process	IEA