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Gene Information
Gene ID:83572
Full Name:platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
Organism:Rattus norvegicus (Rat)
Genetic Location:10q24
Physical Location:61955347-62037870 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pafah1b1
Fold Change:-1.19
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031763.3NP_113951.1NC_005109.2 range: 61955347..62037870, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0030426growth coneCellular ComponentIDA (11056530)
GO:0031965nuclear membraneCellular ComponentIEA
GO:0042598vesicular fractionCellular ComponentIDA (11056530)
GO:0043025cell somaCellular ComponentIDA (11056530)
GO:0005875microtubule associated complexCellular ComponentIEA
GO:0005874microtubuleCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005819spindleCellular ComponentIEA
GO:0005813centrosomeCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005626insoluble fractionCellular ComponentIDA (11056530)
GO:0005625soluble fractionCellular ComponentIDA (11056530)
GO:0008017microtubule bindingMolecular FunctionIEA
GO:0047179platelet-activating factor acetyltransferase activityMolecular FunctionTAS (9459487)
GO:0045505dynein intermediate chain bindingMolecular FunctionIDA (11056530)
GO:0005515protein bindingMolecular FunctionIEA
GO:0047496vesicle transport along microtubuleBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
GO:0017145stem cell divisionBiological ProcessIMP (16144905)
GO:0016042lipid catabolic processBiological ProcessIEA
GO:0000226microtubule cytoskeleton organization and biogenesisBiological ProcessIEA
GO:0008090retrograde axon cargo transportBiological ProcessIEA
GO:0001675acrosome formationBiological ProcessIEA
GO:0001764neuron migrationBiological ProcessIEA
GO:0001764neuron migrationBiological ProcessIMP (16144905)
GO:0006810transportBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0007067mitosisBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007399nervous system developmentBiological ProcessIEA
GO:0007405neuroblast proliferationBiological ProcessIEA
GO:0051301cell divisionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:83572