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Gene Information
Gene ID:83581
Full Name:RNA polymerase 1-4
Organism:Rattus norvegicus (Rat)
Genetic Location:4q33
Physical Location:105187425-105251390 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 25885    Symbol (Name): POLR1A (polymerase (RNA) I polypeptide A, 194kDa)
Ortholog Status:The human GeneID 25885 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rpo1-4
Fold Change:1.16
P Value:0.005
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031772.1NP_113960.1NC_005103.2 range: 105187425..105251390
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005736DNA-directed RNA polymerase I complexCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0003899DNA-directed RNA polymerase activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0016779nucleotidyltransferase activityMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:83581