ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pias3

Full Name:

protein inhibitor of activated STAT 3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

191499054-191507220 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10401 Symbol (Name): PIAS3 (protein inhibitor of activated STAT, 3)

Ortholog Status:

The human GeneID 10401 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.14548
Original ID2:		KChAP
Fold Change:		1.15
P Value:		0.00893
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031784.2	NP_113972.2	NC_005101.2 range: 191499054..191507220

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045202	synapse	Cellular Component	IDA (17486098)
GO:0016607	nuclear speck	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0030425	dendrite	Cellular Component	IDA (17486098)
GO:0019789	SUMO ligase activity	Molecular Function	ISS
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0047485	protein N-terminus binding	Molecular Function	IPI (9565597)
GO:0015459	potassium channel regulator activity	Molecular Function	IDA (9565597)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008022	protein C-terminus binding	Molecular Function	IPI (9565597\|17486098)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (10794667)
GO:0051059	NF-kappaB binding	Molecular Function	ISS
GO:0016925	protein sumoylation	Biological Process	ISS
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA