ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dedd

Full Name:

death effector domain-containing

Alias:

Deft

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q24

Physical Location:

87238314-87241702 on NC_005112.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9191 Symbol (Name): DEDD (death effector domain containing)

Ortholog Status:

The human GeneID 9191 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dedd
Fold Change:		1.19
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031800.1	NP_113988.1	NC_005112.2 range: 87238314..87241702

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005730	nucleolus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0003677	DNA binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0007283	spermatogenesis	Biological Process	IEP (9832420)
GO:0006917	induction of apoptosis	Biological Process	ISS
GO:0006915	apoptosis	Biological Process	NAS (9832420)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0042981	regulation of apoptosis	Biological Process	IEA