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Gene Information
Gene ID:83631
Full Name:death effector domain-containing
Organism:Rattus norvegicus (Rat)
Genetic Location:13q24
Physical Location:87238314-87241702 on NC_005112.2
Gene Type:protein-coding
Human Ortholog:GeneID: 9191    Symbol (Name): DEDD (death effector domain containing)
Ortholog Status:The human GeneID 9191 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dedd
Fold Change:1.19
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031800.1NP_113988.1NC_005112.2 range: 87238314..87241702
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005730nucleolusCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0016481negative regulation of transcriptionBiological ProcessISS
GO:0007283spermatogenesisBiological ProcessIEP (9832420)
GO:0006917induction of apoptosisBiological ProcessISS
GO:0006915apoptosisBiological ProcessNAS (9832420)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0042981regulation of apoptosisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:83631