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Gene Information
Gene ID:83789
Symbol:Rps2
Full Name:ribosomal protein S2
Alias:Rps2r1
Organism:Rattus norvegicus (Rat)
Chromosome:10
Genetic Location:10q12
Physical Location:13975349-13977198 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6187    Symbol (Name): RPS2 (ribosomal protein S2)
Ortholog Status:The human GeneID 6187 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.2115
Original ID2:Rps2
Fold Change:1.33
P Value:0.00003
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Rps2
Fold Change:-1.48
Tissue:Accumbens
Gene Information
Original ID1:Rps2
Fold Change:-1.63
Tissue:Amygdala
Gene Information
Original ID1:Rps2
Fold Change:-1.76
Tissue:Frontalcortex
Gene Information
Original ID1:Rps2
Fold Change:-1.53
Tissue:Hippocampus
Gene Information
Original ID1:Rps2
Fold Change:-1.64
Tissue:Caudate-putamen
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031838.3NP_114026.3NC_005109.2 range: 13975349..13977198
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005840ribosomeCellular ComponentIEA
GO:0015935small ribosomal subunitCellular ComponentIEA
GO:0022627cytosolic small ribosomal subunitCellular ComponentIDA (2328735)
GO:0022627cytosolic small ribosomal subunitCellular ComponentISS
GO:0003723RNA bindingMolecular FunctionIEA
GO:0003735structural constituent of ribosomeMolecular FunctionIEA
GO:0003735structural constituent of ribosomeMolecular FunctionISS
GO:0006412translationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:83789
RGD:619887
Ensembl:ENSRNOG00000014179
dbSNP:Rps2