ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Crot

Full Name:

carnitine O-octanoyltransferase

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q12

Physical Location:

22023912-22067028 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54677 Symbol (Name): CROT (carnitine O-octanoyltransferase)

Ortholog Status:

The human GeneID 54677 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.4896
Original ID2:		Crot
Fold Change:		1.58
P Value:		0.0001
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031987.1	NP_114193.1	NC_005103.2 range: 22023912..22067028, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005777	peroxisome	Cellular Component	ISS
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0008458	carnitine O-octanoyltransferase activity	Molecular Function	ISS
GO:0008458	carnitine O-octanoyltransferase activity	Molecular Function	TAS (7495866)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0001579	medium-chain fatty acid transport	Biological Process	TAS (11790793)
GO:0015908	fatty acid transport	Biological Process	ISS
GO:0015909	long-chain fatty acid transport	Biological Process	TAS (11790793)