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Gene Information
Gene ID:84353
Symbol:Ctnnb1
Full Name:catenin (cadherin associated protein), beta 1
Alias:Catnb
Organism:Rattus norvegicus (Rat)
Chromosome:8
Genetic Location:8q32
Physical Location:125978160-125987669 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1499    Symbol (Name): CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa)
Ortholog Status:The human GeneID 1499 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ctnnb1
Fold Change:1.25
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053357.2NP_445809.2NC_005107.2 range: 125978160..125987669
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005916fascia adherensCellular ComponentISS
GO:0005667transcription factor complexCellular ComponentISS
GO:0005667transcription factor complexCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (17170212)
GO:0005624membrane fractionCellular ComponentISS
GO:0005624membrane fractionCellular ComponentIEA
GO:0016020membraneCellular ComponentISS
GO:0016323basolateral plasma membraneCellular ComponentIEA
GO:0016323basolateral plasma membraneCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005916fascia adherensCellular ComponentIEA
GO:0005913cell-cell adherens junctionCellular ComponentISS
GO:0005913cell-cell adherens junctionCellular ComponentIDA (12533412)
GO:0005912adherens junctionCellular ComponentISS
GO:0005911intercellular junctionCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005829cytosolCellular ComponentIDA (17170212)
GO:0030877beta-catenin destruction complexCellular ComponentISS
GO:0016328lateral plasma membraneCellular ComponentIEA
GO:0031528microvillus membraneCellular ComponentISS
GO:0043296apical junction complexCellular ComponentIEA
GO:0045177apical part of cellCellular ComponentIEA
GO:0043198dendritic shaftCellular ComponentIDA (12123611)
GO:0043005neuron projectionCellular ComponentIDA (16303851)
GO:0045177apical part of cellCellular ComponentISS
GO:0031528microvillus membraneCellular ComponentIEA
GO:0030877beta-catenin destruction complexCellular ComponentIEA
GO:0030027lamellipodiumCellular ComponentISS
GO:0030027lamellipodiumCellular ComponentIEA
GO:0045202synapseCellular ComponentIDA (12123611)
GO:0005737cytoplasmCellular ComponentTAS (9515794)
GO:0016328lateral plasma membraneCellular ComponentISS
GO:0030018Z discCellular ComponentISS
GO:0030018Z discCellular ComponentIEA
GO:0043234protein complexCellular ComponentIDA (12533412)
GO:0043296apical junction complexCellular ComponentISS
GO:0045296cadherin bindingMolecular FunctionIPI (12533412)
GO:0003682chromatin bindingMolecular FunctionISS
GO:0045296cadherin bindingMolecular FunctionISS
GO:0008022protein C-terminus bindingMolecular FunctionIEA
GO:0045296cadherin bindingMolecular FunctionIEA
GO:0045296cadherin bindingMolecular FunctionIDA (9515794|12123611)
GO:0045294alpha-catenin bindingMolecular FunctionISS
GO:0045294alpha-catenin bindingMolecular FunctionIEA
GO:0008134transcription factor bindingMolecular FunctionIEA
GO:0008134transcription factor bindingMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionISS
GO:0008022protein C-terminus bindingMolecular FunctionISS
GO:0003713transcription coactivator activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15659388|17170212)
GO:0003690double-stranded DNA bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIDA (16617054)
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0003713transcription coactivator activityMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionISS
GO:0003682chromatin bindingMolecular FunctionIEA
GO:0003690double-stranded DNA bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0000904cellular morphogenesis during differentiationBiological ProcessISS
GO:0042475odontogenesis of dentine-containing teethBiological ProcessISS
GO:0042475odontogenesis of dentine-containing teethBiological ProcessIEP (10681393)
GO:0000904cellular morphogenesis during differentiationBiological ProcessIEA
GO:0042475odontogenesis of dentine-containing teethBiological ProcessIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0045453bone resorptionBiological ProcessIEA
GO:0042127regulation of cell proliferationBiological ProcessISS
GO:0042127regulation of cell proliferationBiological ProcessIEA
GO:0035117embryonic arm morphogenesisBiological ProcessISS
GO:0001709cell fate determinationBiological ProcessIEA
GO:0001501skeletal developmentBiological ProcessIEA
GO:0001501skeletal developmentBiological ProcessISS
GO:0001709cell fate determinationBiological ProcessISS
GO:0042733embryonic digit morphogenesisBiological ProcessISS
GO:0001708cell fate specificationBiological ProcessISS
GO:0001708cell fate specificationBiological ProcessIEA
GO:0001706endoderm formationBiological ProcessISS
GO:0043627response to estrogen stimulusBiological ProcessIDA (17170212)
GO:0042733embryonic digit morphogenesisBiological ProcessIEA
GO:0001702gastrulation with mouth forming secondBiological ProcessISS
GO:0001569patterning of blood vesselsBiological ProcessISS
GO:0001569patterning of blood vesselsBiological ProcessIEA
GO:0001706endoderm formationBiological ProcessIEA
GO:0045445myoblast differentiationBiological ProcessIEP (17222478)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0046686response to cadmium ionBiological ProcessIEP (17136310)
GO:0048469cell maturationBiological ProcessIEA
GO:0048469cell maturationBiological ProcessISS
GO:0048489synaptic vesicle transportBiological ProcessIEA
GO:0048593camera-type eye morphogenesisBiological ProcessIEA
GO:0048593camera-type eye morphogenesisBiological ProcessISS
GO:0050808synapse organization and biogenesisBiological ProcessIEA
GO:0050808synapse organization and biogenesisBiological ProcessISS
GO:0060070Wnt receptor signaling pathway through beta-cateninBiological ProcessIEA
GO:0045941positive regulation of transcriptionBiological ProcessISS
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessISS
GO:0045449regulation of transcriptionBiological ProcessISS
GO:0048489synaptic vesicle transportBiological ProcessISS
GO:0045453bone resorptionBiological ProcessISS
GO:0045595regulation of cell differentiationBiological ProcessISS
GO:0045596negative regulation of cell differentiationBiological ProcessISS
GO:0045667regulation of osteoblast differentiationBiological ProcessISS
GO:0045669positive regulation of osteoblast differentiationBiological ProcessIEA
GO:0045669positive regulation of osteoblast differentiationBiological ProcessISS
GO:0045671negative regulation of osteoclast differentiationBiological ProcessIEA
GO:0045671negative regulation of osteoclast differentiationBiological ProcessISS
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessISS
GO:0060070Wnt receptor signaling pathway through beta-cateninBiological ProcessISS
GO:0006915apoptosisBiological ProcessISS
GO:0009950dorsal/ventral axis specificationBiological ProcessISS
GO:0009953dorsal/ventral pattern formationBiological ProcessISS
GO:0009954proximal/distal pattern formationBiological ProcessIEA
GO:0009954proximal/distal pattern formationBiological ProcessISS
GO:0009987cellular processBiological ProcessISS
GO:0014010Schwann cell proliferationBiological ProcessIMP (17941050)
GO:0014070response to organic cyclic substanceBiological ProcessIEP (18174280)
GO:0016055Wnt receptor signaling pathwayBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0016331morphogenesis of embryonic epitheliumBiological ProcessIEA
GO:0009950dorsal/ventral axis specificationBiological ProcessIEA
GO:0009725response to hormone stimulusBiological ProcessIEP (17708712)
GO:0008283cell proliferationBiological ProcessISS
GO:0007160cell-matrix adhesionBiological ProcessISS
GO:0007268synaptic transmissionBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessISS
GO:0007398ectoderm developmentBiological ProcessIEA
GO:0007398ectoderm developmentBiological ProcessISS
GO:0007494midgut developmentBiological ProcessIEP (17356920)
GO:0007507heart developmentBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIEA
GO:0016331morphogenesis of embryonic epitheliumBiological ProcessISS
GO:0016337cell-cell adhesionBiological ProcessIDA (12533412)
GO:0030900forebrain developmentBiological ProcessISS
GO:0031016pancreas developmentBiological ProcessIEA
GO:0031016pancreas developmentBiological ProcessISS
GO:0001711endodermal cell fate commitmentBiological ProcessISS
GO:0001711endodermal cell fate commitmentBiological ProcessIEA
GO:0032331negative regulation of chondrocyte differentiationBiological ProcessIEA
GO:0032331negative regulation of chondrocyte differentiationBiological ProcessISS
GO:0034097response to cytokine stimulusBiological ProcessIDA (17888912)
GO:0035116embryonic hindlimb morphogenesisBiological ProcessIEA
GO:0035116embryonic hindlimb morphogenesisBiological ProcessISS
GO:0030900forebrain developmentBiological ProcessIEA
GO:0007507heart developmentBiological ProcessISS
GO:0001889liver developmentBiological ProcessIEP (17236583)
GO:0016337cell-cell adhesionBiological ProcessISS
GO:0030097hemopoiesisBiological ProcessIEA
GO:0030097hemopoiesisBiological ProcessISS
GO:0030154cell differentiationBiological ProcessISS
GO:0030316osteoclast differentiationBiological ProcessIEA
GO:0030316osteoclast differentiationBiological ProcessISS
GO:0030324lung developmentBiological ProcessIEA
GO:0030324lung developmentBiological ProcessISS
GO:0030858positive regulation of epithelial cell differentiationBiological ProcessIEA
GO:0030858positive regulation of epithelial cell differentiationBiological ProcessISS
GO:0035117embryonic arm morphogenesisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:84353
RGD:70487
Ensembl:ENSRNOG00000019139
dbSNP:Ctnnb1