Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:84360
Full Name:chloride channel 3
Organism:Rattus norvegicus (Rat)
Genetic Location:16p12
Physical Location:32446963-32517483 on NC_005115.2
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Clcn3
Fold Change:1.18
P Value:0.002
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Clcn3
Fold Change:1.15
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053363.2NP_445815.2NC_005115.2 range: 32446963..32517483
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0012506vesicle membraneCellular ComponentISS
GO:0016020membraneCellular ComponentIDA (10915634)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIDA (10915634)
GO:0005794Golgi apparatusCellular ComponentISS
GO:0005770late endosomeCellular ComponentISS
GO:0005769early endosomeCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016324apical plasma membraneCellular ComponentIDA (12475763)
GO:0031901early endosome membraneCellular ComponentIEA
GO:0031902late endosome membraneCellular ComponentIEA
GO:0030165PDZ domain bindingMolecular FunctionISS
GO:0031404chloride ion bindingMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIDA (10915634)
GO:0005254chloride channel activityMolecular FunctionIDA (10915634)
GO:0046982protein heterodimerization activityMolecular FunctionISS
GO:0005244voltage-gated ion channel activityMolecular FunctionIDA (10915634)
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005247voltage-gated chloride channel activityMolecular FunctionIDA (10915634)
GO:0005247voltage-gated chloride channel activityMolecular FunctionIEA
GO:0006821chloride transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIDA (10915634)
GO:0006811ion transportBiological ProcessIEA
GO:0006821chloride transportBiological ProcessIDA (10915634)
Other Database Cross Links
NCBI Entrez Gene:84360