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Gene Information
Gene ID:84390
Symbol:Hcn1
Full Name:hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q15
Physical Location:49525948-49939065 on NC_005101.2
Gene Type:protein-coding
Human Ortholog:GeneID: 348980    Symbol (Name): HCN1 (hyperpolarization activated cyclic nucleotide-gated potassium channel 1)
Ortholog Status:The human GeneID 348980 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hcn1
Fold Change:1.23
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053375.1NP_445827.1NC_005101.2 range: 49525948..49939065
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0030424axonCellular ComponentIEA
GO:0030424axonCellular ComponentISS
GO:0030425dendriteCellular ComponentIEA
GO:0030425dendriteCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0030552cAMP bindingMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005272sodium channel activityMolecular FunctionIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0045176apical protein localizationBiological ProcessIEA
GO:0006814sodium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0045176apical protein localizationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:84390
RGD:620688
Ensembl:ENSRNOG00000011522
dbSNP:Hcn1