ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hcn1

Full Name:

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q15

Physical Location:

49525948-49939065 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 348980 Symbol (Name): HCN1 (hyperpolarization activated cyclic nucleotide-gated potassium channel 1)

Ortholog Status:

The human GeneID 348980 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hcn1
Fold Change:		1.23
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053375.1	NP_445827.1	NC_005101.2 range: 49525948..49939065

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030424	axon	Cellular Component	IEA
GO:0030424	axon	Cellular Component	ISS
GO:0030425	dendrite	Cellular Component	IEA
GO:0030425	dendrite	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	IEA
GO:0030552	cAMP binding	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005272	sodium channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA
GO:0045176	apical protein localization	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0045176	apical protein localization	Biological Process	ISS