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Gene Information
Gene ID:84403
Full Name:gap junction membrane channel protein beta 6
Organism:Rattus norvegicus (Rat)
Genetic Location:15p12
Physical Location:36177732-36186512 on NC_005114.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10804    Symbol (Name): GJB6 (gap junction protein, beta 6, 30kDa)
Ortholog Status:The human GeneID 10804 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gjb6
Fold Change:1.15
P Value:0.005
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053388.1NP_445840.1NC_005114.2 range: 36177732..36186512, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016324apical plasma membraneCellular ComponentIDA (16077080)
GO:0030054cell junctionCellular ComponentIEA
GO:0005922connexon complexCellular ComponentIEA
GO:0005921gap junctionCellular ComponentISS
GO:0005921gap junctionCellular ComponentIDA (10197766)
GO:0005829cytosolCellular ComponentIDA (16077080)
GO:0005515protein bindingMolecular FunctionISS
GO:0003674molecular_functionMolecular FunctionND
GO:0042471ear morphogenesisBiological ProcessISS
GO:0008285negative regulation of cell proliferationBiological ProcessIDA (11238193)
GO:0007605sensory perception of soundBiological ProcessISS
GO:0007154cell communicationBiological ProcessNAS (12359154)
GO:0007154cell communicationBiological ProcessIEA
GO:0006915apoptosisBiological ProcessIEP (12359154)
GO:0048839inner ear developmentBiological ProcessIEP (10570462)
Other Database Cross Links
NCBI Entrez Gene:84403