ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gjb6

Full Name:

gap junction membrane channel protein beta 6

Alias:

Cx30

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

15p12

Physical Location:

36177732-36186512 on NC_005114.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10804 Symbol (Name): GJB6 (gap junction protein, beta 6, 30kDa)

Ortholog Status:

The human GeneID 10804 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gjb6
Fold Change:		1.15
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053388.1	NP_445840.1	NC_005114.2 range: 36177732..36186512, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016324	apical plasma membrane	Cellular Component	IDA (16077080)
GO:0030054	cell junction	Cellular Component	IEA
GO:0005922	connexon complex	Cellular Component	IEA
GO:0005921	gap junction	Cellular Component	ISS
GO:0005921	gap junction	Cellular Component	IDA (10197766)
GO:0005829	cytosol	Cellular Component	IDA (16077080)
GO:0005515	protein binding	Molecular Function	ISS
GO:0003674	molecular_function	Molecular Function	ND
GO:0042471	ear morphogenesis	Biological Process	ISS
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA (11238193)
GO:0007605	sensory perception of sound	Biological Process	ISS
GO:0007154	cell communication	Biological Process	NAS (12359154)
GO:0007154	cell communication	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEP (12359154)
GO:0048839	inner ear development	Biological Process	IEP (10570462)