ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

84405

Symbol:

Il12a

Full Name:

interleukin 12a

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q31

Physical Location:

158710260-158717688 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3592 Symbol (Name): IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35))

Ortholog Status:

The human GeneID 3592 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Il12a
Fold Change:		1.16
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053390.1	NP_445842.1	NC_005101.2 range: 158710260..158717688

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IEA
GO:0043514	interleukin-12 complex	Cellular Component	ISS
GO:0005615	extracellular space	Cellular Component	ISS
GO:0005576	extracellular region	Cellular Component	IEA
GO:0042163	interleukin-12 beta subunit binding	Molecular Function	ISS
GO:0045513	interleukin-27 binding	Molecular Function	IEA
GO:0045513	interleukin-27 binding	Molecular Function	ISS
GO:0042163	interleukin-12 beta subunit binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0046982	protein heterodimerization activity	Molecular Function	ISS
GO:0005125	cytokine activity	Molecular Function	IDA (12471147)
GO:0005125	cytokine activity	Molecular Function	IEA
GO:0005125	cytokine activity	Molecular Function	ISS
GO:0005143	interleukin-12 receptor binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0045785	positive regulation of cell adhesion	Biological Process	ISS
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	Biological Process	ISS
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	Biological Process	IEA
GO:0001916	positive regulation of T cell mediated cytotoxicity	Biological Process	ISS
GO:0042102	positive regulation of T cell proliferation	Biological Process	ISS
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	Biological Process	ISS
GO:0006955	immune response	Biological Process	IEA
GO:0010224	response to UV-B	Biological Process	ISS
GO:0016477	cell migration	Biological Process	ISS
GO:0032496	response to lipopolysaccharide	Biological Process	ISS
GO:0032729	positive regulation of interferon-gamma production	Biological Process	ISS
GO:0032816	positive regulation of natural killer cell activation	Biological Process	ISS
GO:0042102	positive regulation of T cell proliferation	Biological Process	IEA
GO:0050830	defense response to Gram-positive bacterium	Biological Process	ISS