ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc4a4

Full Name:

solute carrier family 4 (anion exchanger), member 4

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14p22

Physical Location:

20381544-20739215 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8671 Symbol (Name): SLC4A4 (solute carrier family 4, sodium bicarbonate cotransporter, member 4)

Ortholog Status:

The human GeneID 8671 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slc4a4
Fold Change:		1.22
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053424.1	NP_445876.1	NC_005113.2 range: 20381544..20739215, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (11788449)
GO:0008510	sodium:bicarbonate symporter activity	Molecular Function	TAS (11788449)
GO:0006814	sodium ion transport	Biological Process	ISS
GO:0006885	regulation of pH	Biological Process	TAS (11788449)