ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CUL1

Full Name:

cullin 1

Alias:

MGC149834|MGC149835

Organism:

Homo sapiens (Human)

Chromosome:

7

Genetic Location:

7q36.1

Physical Location:

148026865-148129134 on NC_000007.12

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.146806
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003592.2	NP_003583.2	NC_000007.12 range: 148026865..148129134

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	EXP (11231585)
GO:0005829	cytosol	Cellular Component	EXP (12820959\|15469984)
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (12504025)
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	TAS (8681378)
GO:0008629	induction of apoptosis by intracellular signals	Biological Process	TAS (8681378)
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS (8681378)
GO:0007050	cell cycle arrest	Biological Process	TAS (8681378)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000055130

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: