ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pola2

Full Name:

polymerase (DNA directed), alpha 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q43

Physical Location:

208573152-208597194 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23649 Symbol (Name): POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))

Ortholog Status:

The human GeneID 23649 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pola2
Fold Change:		1.2
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053480.2	NP_445932.2	NC_005100.2 range: 208573152..208597194, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005658	alpha DNA polymerase:primase complex	Cellular Component	TAS (11536367)
GO:0005658	alpha DNA polymerase:primase complex	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IMP (11536367)
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0006260	DNA replication	Biological Process	IEA
GO:0006260	DNA replication	Biological Process	ISS
GO:0006260	DNA replication	Biological Process	TAS (11536367)
GO:0000060	protein import into nucleus, translocation	Biological Process	ISS