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Gene Information
Gene ID:85242
Symbol:Pola2
Full Name:polymerase (DNA directed), alpha 2
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q43
Physical Location:208573152-208597194 on NC_005100.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 23649    Symbol (Name): POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))
Ortholog Status:The human GeneID 23649 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pola2
Fold Change:1.2
P Value:0.003
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053480.2NP_445932.2NC_005100.2 range: 208573152..208597194, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005658alpha DNA polymerase:primase complexCellular ComponentTAS (11536367)
GO:0005658alpha DNA polymerase:primase complexCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0046982protein heterodimerization activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0003887DNA-directed DNA polymerase activityMolecular FunctionIMP (11536367)
GO:0003887DNA-directed DNA polymerase activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0006260DNA replicationBiological ProcessIEA
GO:0006260DNA replicationBiological ProcessISS
GO:0006260DNA replicationBiological ProcessTAS (11536367)
GO:0000060protein import into nucleus, translocationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:85242
RGD:621817
Ensembl:ENSRNOG00000020906
dbSNP:Pola2