ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

APOL1

Full Name:

apolipoprotein L, 1

Alias:

APO-L|APOL|APOL-I

Organism:

Homo sapiens (Human)

Chromosome:

22

Genetic Location:

22q13.1

Physical Location:

34979069-34993522 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.114309
Note:		"Class I, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003661.2	NP_003652.2	NC_000022.9 range: 34979069..34993522
NM_145343.1	NP_663318.1	NC_000022.9 range: 34979069..34993522

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031224	intrinsic to membrane	Cellular Component	IC (16020735)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (9325276\|17192540)
GO:0005254	chloride channel activity	Molecular Function	IDA (16020735)
GO:0008289	lipid binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12621437)
GO:0005319	lipid transporter activity	Molecular Function	IEA
GO:0031640	killing of cells of another organism	Biological Process	IDA (12621437\|17192540)
GO:0019835	cytolysis	Biological Process	IDA (12621437\|17192540)
GO:0042157	lipoprotein metabolic process	Biological Process	IEA
GO:0008203	cholesterol metabolic process	Biological Process	IEA
GO:0008202	steroid metabolic process	Biological Process	IEA
GO:0006869	lipid transport	Biological Process	IEA
GO:0006821	chloride transport	Biological Process	IDA (16020735)
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0045087	innate immune response	Biological Process	IDA (17192540)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000100342

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: