Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:8542
Full Name:apolipoprotein L, 1
Organism:Homo sapiens (Human)
Genetic Location:22q13.1
Physical Location:34979069-34993522 on NC_000022.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.114309
Note:"Class I, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003661.2NP_003652.2NC_000022.9 range: 34979069..34993522
NM_145343.1NP_663318.1NC_000022.9 range: 34979069..34993522
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0031224intrinsic to membraneCellular ComponentIC (16020735)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIDA (9325276|17192540)
GO:0005254chloride channel activityMolecular FunctionIDA (16020735)
GO:0008289lipid bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12621437)
GO:0005319lipid transporter activityMolecular FunctionIEA
GO:0031640killing of cells of another organismBiological ProcessIDA (12621437|17192540)
GO:0019835cytolysisBiological ProcessIDA (12621437|17192540)
GO:0042157lipoprotein metabolic processBiological ProcessIEA
GO:0008203cholesterol metabolic processBiological ProcessIEA
GO:0008202steroid metabolic processBiological ProcessIEA
GO:0006869lipid transportBiological ProcessIEA
GO:0006821chloride transportBiological ProcessIDA (16020735)
GO:0006629lipid metabolic processBiological ProcessIEA
GO:0045087innate immune responseBiological ProcessIDA (17192540)
Other Database Cross Links
NCBI Entrez Gene:8542
HuGE Navigator:8542