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Gene Information
Gene ID:8612
Symbol:PPAP2C
Full Name:phosphatidic acid phosphatase type 2C
Alias:LPP2|PAP-2c|PAP2-g
Organism:Homo sapiens (Human)
Chromosome:19
Genetic Location:19p13
Physical Location:232042-242434 on NC_000019.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.465506
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003712.2NP_003703.1NC_000019.8 range: 232042..242434, complement
NM_177526.1NP_803545.1NC_000019.8 range: 232042..242434, complement
NM_177543.1NP_808211.1NC_000019.8 range: 232042..242434, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (9705349)
GO:0016020membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentTAS (9607309)
GO:0016021integral to membraneCellular ComponentIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionTAS (9607309)
GO:0008195phosphatidate phosphatase activityMolecular FunctionEXP (9705349)
GO:0008195phosphatidate phosphatase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:8612
HGNC:9230
Ensembl:ENSG00000141934
MIM:607126
HPRD:06180
HuGE Navigator:8612
dbSNP:PPAP2C
GeneCard:PPAP2C
AceView:PPAP2C