ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

AKR1C3

Full Name:

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p15-p14

Physical Location:

5126567-5139877 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D17793
Fold Change:		2.03

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003739.4	NP_003730.4	NC_000010.9 range: 5126567..5139877

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IDA (11256614)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004033	aldo-keto reductase activity	Molecular Function	TAS (9792917)
GO:0050327	testosterone 17-beta-dehydrogenase activity	Molecular Function	IEA
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	Molecular Function	IEA
GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity	Molecular Function	IEA
GO:0047026	3-alpha-hydroxysteroid dehydrogenase (A-specific) activity	Molecular Function	IEA
GO:0047017	prostaglandin-F synthase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0006693	prostaglandin metabolic process	Biological Process	TAS (9792917)
GO:0055114	oxidation reduction	Biological Process	TAS (9792917)