ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TNKS

Full Name:

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p23.1

Physical Location:

9450854-9677265 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 21951 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.370267
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D8S550

10918926

Region:		8918926-12918926
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003747.2	NP_003738.2	NC_000008.9 range: 9450854..9677265

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005694	chromosome	Cellular Component	IEA
GO:0005643	nuclear pore	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0000781	chromosome, telomeric region	Cellular Component	IDA (9822378)
GO:0003950	NAD+ ADP-ribosyltransferase activity	Molecular Function	IDA (9822378)
GO:0005515	protein binding	Molecular Function	IPI (9822378\|12768206)
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0007004	telomere maintenance via telomerase	Biological Process	NAS (9822378)
GO:0015031	protein transport	Biological Process	IEA
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA (17026964)
GO:0018107	peptidyl-threonine phosphorylation	Biological Process	IDA (17026964)
GO:0051028	mRNA transport	Biological Process	IEA
GO:0065002	intracellular protein transport across a membrane	Biological Process	IEA