ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IRS2

Full Name:

insulin receptor substrate 2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q34

Physical Location:

109204184-109236914 on NC_000013.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 384783 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

IRS2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S1265

108126458

Region:		106126458-110126458
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003749.2	NP_003740.2	NC_000013.9 range: 109204184..109236914, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	EXP (12167717)
GO:0004871	signal transducer activity	Molecular Function	TAS (7675087\|9495343)
GO:0005158	insulin receptor binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0006006	glucose metabolic process	Biological Process	TAS (9495343)
GO:0007165	signal transduction	Biological Process	TAS (7675087)
GO:0008284	positive regulation of cell proliferation	Biological Process	NR