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Gene Information
Gene ID:384783
Symbol:Irs2
Full Name:insulin receptor substrate 2
Alias:Irs-2
Organism:Mus musculus (Mouse)
Chromosome:8
Genetic Location:8 A1.1
Physical Location:10986960-11008429 on NC_000074.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8660    Symbol (Name): IRS2 (insulin receptor substrate 2)
Ortholog Status:The human GeneID 8660 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Irs2
Original ID2:AF090738
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001081212.1NP_001074681.1NC_000074.5 range: 10986960..11008429, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (11147812)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005158insulin receptor bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11018022)
GO:0019901protein kinase bindingMolecular FunctionIDA (14733908)
GO:0002053positive regulation of mesenchymal cell proliferationBiological ProcessIGI (17662267)
GO:0030335positive regulation of cell migrationBiological ProcessIGI (17662267)
GO:0008286insulin receptor signaling pathwayBiological ProcessIMP (12488434)
GO:0008283cell proliferationBiological ProcessIMP (12904469)
GO:0007420brain developmentBiological ProcessIMP (12904469)
GO:0007165signal transductionBiological ProcessIEA
GO:0030879mammary gland developmentBiological ProcessIGI (17662267)
Other Database Cross Links
NCBI Entrez Gene:384783
MGI:
Ensembl:ENSMUSG00000038894
dbSNP:Irs2
AceView:Irs2