ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Irs2

Full Name:

insulin receptor substrate 2

Alias:

Irs-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 A1.1

Physical Location:

10986960-11008429 on NC_000074.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8660 Symbol (Name): IRS2 (insulin receptor substrate 2)

Ortholog Status:

The human GeneID 8660 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Irs2
Original ID2:		AF090738

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001081212.1	NP_001074681.1	NC_000074.5 range: 10986960..11008429, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (11147812)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005158	insulin receptor binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11018022)
GO:0019901	protein kinase binding	Molecular Function	IDA (14733908)
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process	IGI (17662267)
GO:0030335	positive regulation of cell migration	Biological Process	IGI (17662267)
GO:0008286	insulin receptor signaling pathway	Biological Process	IMP (12488434)
GO:0008283	cell proliferation	Biological Process	IMP (12904469)
GO:0007420	brain development	Biological Process	IMP (12904469)
GO:0007165	signal transduction	Biological Process	IEA
GO:0030879	mammary gland development	Biological Process	IGI (17662267)