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Gene Information
Gene ID:8767
Full Name:receptor-interacting serine-threonine kinase 2
Organism:Homo sapiens (Human)
Genetic Location:8q21
Physical Location:90839109-90872432 on NC_000008.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.103755
Note:"Class I, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003821.5NP_003812.1NC_000008.9 range: 90839109..90872432
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentEXP (17468049)
GO:0005622intracellularCellular ComponentIEA
GO:0030274LIM domain bindingMolecular FunctionIPI (15657077)
GO:0016740transferase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionEXP (17468049)
GO:0050700CARD domain bindingMolecular FunctionIPI (11087742)
GO:0004674protein serine/threonine kinase activityMolecular FunctionTAS (9642260)
GO:0004871signal transducer activityMolecular FunctionIEP (12761501)
GO:0004872receptor activityMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006954inflammatory responseBiological ProcessTAS (9705938)
GO:0042981regulation of apoptosisBiological ProcessIEA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIEP (12761501)
GO:0007165signal transductionBiological ProcessTAS (9642260)
Other Database Cross Links
NCBI Entrez Gene:8767
HuGE Navigator:8767