ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RIPK2

Full Name:

receptor-interacting serine-threonine kinase 2

Alias:

CARD3|CARDIAK|CCK|GIG30|RICK|RIP2

Organism:

Homo sapiens (Human)

Chromosome:

8

Genetic Location:

8q21

Physical Location:

90839109-90872432 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.103755
Note:		"Class I, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003821.5	NP_003812.1	NC_000008.9 range: 90839109..90872432

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (17468049)
GO:0005622	intracellular	Cellular Component	IEA
GO:0030274	LIM domain binding	Molecular Function	IPI (15657077)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	EXP (17468049)
GO:0050700	CARD domain binding	Molecular Function	IPI (11087742)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (9642260)
GO:0004871	signal transducer activity	Molecular Function	IEP (12761501)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006954	inflammatory response	Biological Process	TAS (9705938)
GO:0042981	regulation of apoptosis	Biological Process	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEP (12761501)
GO:0007165	signal transduction	Biological Process	TAS (9642260)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000104312

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: