ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NRP1

Full Name:

neuropilin 1

Alias:

BDCA4|CD304|DKFZp686A03134|DKFZp781F1414|NP1|NRP|VEGF165R

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p12

Physical Location:

33506431-33663838 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.131704
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (11256614)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	NR
GO:0005576	extracellular region	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (17222790)
GO:0005021	vascular endothelial growth factor receptor activity	Molecular Function	TAS (9288753)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS (9529250)
GO:0009887	organ morphogenesis	Biological Process	TAS (9529250)
GO:0001525	angiogenesis	Biological Process	IEA
GO:0007411	axon guidance	Biological Process	TAS (9288753)
GO:0007399	nervous system development	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007267	cell-cell signaling	Biological Process	TAS (9288753)
GO:0007165	signal transduction	Biological Process	TAS (9288753)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA