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Gene Information
Gene ID:8925
Symbol:HERC1
Full Name:hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
Alias:p532|p619
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q22
Physical Location:61687869-61913199 on NC_000015.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.210385
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003922.3NP_003913.3NC_000015.8 range: 61687869..61913199, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentTAS (8861955)
GO:0005794Golgi apparatusCellular ComponentTAS (8861955)
GO:0004842ubiquitin-protein ligase activityMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0005086ARF guanyl-nucleotide exchange factor activityMolecular FunctionTAS (8861955)
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0006464protein modification processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:8925
HGNC:4867
Ensembl:
MIM:605109
HPRD:06894
HuGE Navigator:8925
dbSNP:HERC1
GeneCard:HERC1
AceView:HERC1