ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HERC1

Full Name:

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1

Alias:

p532|p619

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q22

Physical Location:

61687869-61913199 on NC_000015.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.210385
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003922.3	NP_003913.3	NC_000015.8 range: 61687869..61913199, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	TAS (8861955)
GO:0005794	Golgi apparatus	Cellular Component	TAS (8861955)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0005086	ARF guanyl-nucleotide exchange factor activity	Molecular Function	TAS (8861955)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006464	protein modification process	Biological Process	IEA