ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Chi3l1

Full Name:

chitinase 3-like 1

Alias:

MGC109420

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q13

Physical Location:

47139657-47147590 on NC_005112.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1116 Symbol (Name): CHI3L1 (chitinase 3-like 1 (cartilage glycoprotein-39))

Ortholog Status:

The human GeneID 1116 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Chi3l1
Fold Change:		1.14
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053560.1	NP_446012.1	NC_005112.2 range: 47139657..47147590

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004568	chitinase activity	Molecular Function	IEA
GO:0005529	sugar binding	Molecular Function	IEA
GO:0043169	cation binding	Molecular Function	IEA
GO:0045735	nutrient reservoir activity	Molecular Function	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0006032	chitin catabolic process	Biological Process	IEA