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Gene Information
Gene ID:89824
Full Name:chitinase 3-like 1
Organism:Rattus norvegicus (Rat)
Genetic Location:13q13
Physical Location:47139657-47147590 on NC_005112.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1116    Symbol (Name): CHI3L1 (chitinase 3-like 1 (cartilage glycoprotein-39))
Ortholog Status:The human GeneID 1116 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Chi3l1
Fold Change:1.14
P Value:0.007
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053560.1NP_446012.1NC_005112.2 range: 47139657..47147590
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004568chitinase activityMolecular FunctionIEA
GO:0005529sugar bindingMolecular FunctionIEA
GO:0043169cation bindingMolecular FunctionIEA
GO:0045735nutrient reservoir activityMolecular FunctionIEA
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0006032chitin catabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:89824