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Gene Information
Gene ID:89826
Symbol:Rpe65
Full Name:retinal pigment epithelium 65
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q45
Physical Location:257846391-257879313 on NC_005101.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6121    Symbol (Name): RPE65 (retinal pigment epithelium-specific protein 65kDa)
Ortholog Status:The human GeneID 6121 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rpe65
Fold Change:1.17
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Rpe65
Fold Change:1.14
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053562.1NP_446014.1NC_005101.2 range: 257846391..257879313
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0001654eye developmentBiological ProcessNAS (9512345)
GO:0007468regulation of rhodopsin gene expressionBiological ProcessISS
GO:0007601visual perceptionBiological ProcessIEA
GO:0007601visual perceptionBiological ProcessISS
GO:0042574retinal metabolic processBiological ProcessISS
GO:0050896response to stimulusBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:89826
RGD:621396
Ensembl:ENSRNOG00000009582
dbSNP:Rpe65