ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HGS

Full Name:

hepatocyte growth factor-regulated tyrosine kinase substrate

Alias:

HRS|ZFYVE8

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

77261424-77279552 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15239 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

HGS

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004712.3	NP_004703.1	NC_000017.9 range: 77261424..77279552

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (10567358\|12218189\|15962011)
GO:0031901	early endosome membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (10861283\|15611048)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	TAS (9407053)
GO:0016197	endosome transport	Biological Process	NAS (10861283)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0042176	regulation of protein catabolic process	Biological Process	TAS (15611048)
GO:0046426	negative regulation of JAK-STAT cascade	Biological Process	IDA (12444102)
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS (9407053)